Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients

Maria Grigoroiu-Serbanescu; Carmen C Diaconu; Stefanie Heilmann-Heimbach; Ana Iulia Neagu; Tim Becker

doi:10.1016/j.psychres.2015.11.008

Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients

Psychiatry Res. 2015 Dec 30;230(3):964-7. doi: 10.1016/j.psychres.2015.11.008. Epub 2015 Nov 10.

Authors

Maria Grigoroiu-Serbanescu¹, Carmen C Diaconu², Stefanie Heilmann-Heimbach³, Ana Iulia Neagu², Tim Becker⁴

Affiliations

¹ Alexandru Obregia Clinical Psychiatric Hospital, Biometric Psychiatric Genetics Research Unit, Bucharest, Romania. Electronic address: maria.serbanescu@googlemail.com.
² Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
³ Institute of Human Genetics, Dept. Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
⁴ Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, D-17475 Greifswald, Germany.

PMID: 26596365
DOI: 10.1016/j.psychres.2015.11.008

Abstract

We investigated the influence of the age-of-onset (AO) on the association of 45 loci conferring risk for bipolar disorder (BP) and schizophrenia with BP-type-I in a Romanian sample (461 patients, 436 controls). The AO-analysis implicated the EGFR gene, as well as loci in other genes, in the AO variation of BP-type-I and revealed for the first time the link between BP-type-I and risk variants considered specific to schizophrenia (polymorphisms in MMP16/RIPK2 and CNNM2 genes).

Keywords: CNNM2 genes; EGFR; MMP16.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age of Onset
Bipolar Disorder / genetics*
Female
Genetic Loci*
Genome-Wide Association Study
Humans
Male
Polymorphism, Single Nucleotide*
Risk
Romania
Schizophrenia / genetics*
Young Adult