Prostaglandin E receptor 4 inhibition restores UVB-induced downregulation of ATP2A2/SERCA2 in cultured normal human keratinocytes

J Dermatol Sci. 2016 Jan;81(1):69-71. doi: 10.1016/j.jdermsci.2015.10.010. Epub 2015 Oct 28.

Authors

Maya Kamijo¹, Akino Wada², Reiko Mineki³, Tamami Sakanishi⁴, Shigaku Ikeda⁵

Affiliations

¹ Department of Dermatology and Allergology, Japan. Electronic address: mkamijo@juntendo.ac.jp.
² Department of Dermatology and Allergology, Japan.
³ Laboratory of Proteomics and Biomolecular Science, Research Support Center, Japan.
⁴ Division of Cell Biology, Research Support Center, Japan.
⁵ Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

PMID: 26596216
DOI: 10.1016/j.jdermsci.2015.10.010

No abstract available

Keywords: Calcium; Darier disease; EP4; Prostaglandin E; Ultraviolet B.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Darier Disease / genetics
Darier Disease / metabolism
Darier Disease / therapy
Down-Regulation / drug effects
Down-Regulation / radiation effects
Humans
Keratinocytes / drug effects
Keratinocytes / metabolism*
Keratinocytes / radiation effects*
RNA, Messenger / genetics
RNA, Messenger / metabolism
RNA, Small Interfering / genetics
Receptors, Prostaglandin E, EP4 Subtype / antagonists & inhibitors*
Receptors, Prostaglandin E, EP4 Subtype / genetics
Sarcoplasmic Reticulum Calcium-Transporting ATPases / genetics
Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism*
Ultraviolet Rays
Ultraviolet Therapy

Substances

PTGER4 protein, human
RNA, Messenger
RNA, Small Interfering
Receptors, Prostaglandin E, EP4 Subtype
Sarcoplasmic Reticulum Calcium-Transporting ATPases
ATP2A2 protein, human