Translational Coronary Atherosclerosis Imaging with PET

Philip D Adamson; David E Newby; Marc R Dweck

doi:10.1016/j.ccl.2015.06.002

Translational Coronary Atherosclerosis Imaging with PET

Cardiol Clin. 2016 Feb;34(1):179-86. doi: 10.1016/j.ccl.2015.06.002. Epub 2015 Aug 12.

Authors

Philip D Adamson¹, David E Newby², Marc R Dweck²

Affiliations

¹ Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK. Electronic address: philip.adamson@ed.ac.uk.
² Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.

PMID: 26590788
DOI: 10.1016/j.ccl.2015.06.002

Abstract

Although still in its infancy, coronary atherosclerosis imaging with PET holds promise in improving understanding of the pathophysiologic processes that underlie plaque progression and adverse cardiovascular events. Fludeoxyglucose F 18 offers the potential to measure inflammatory activity within the plaque itself whereas fluoride F 18 allows detection of microcalcification, both of which are key characteristics of plaques at risk of rupture. Further work is required to improve these imaging techniques and to assess their ability to predict cardiac events prospectively.

Keywords: (18)F-FDG; (18)F-NaF; Coronary atherosclerosis; PET; Vulnerable plaque.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Coronary Artery Disease / diagnosis*
Humans
Multimodal Imaging*
Positron-Emission Tomography*
Tomography, X-Ray Computed*

Abstract

Publication types

MeSH terms

Grants and funding