Imaging autofluorescence temporal signatures of the human ocular fundus in vivo

Asael Papour; Zachary Taylor; Oscar Stafsudd; Irena Tsui; Warren Grundfest

doi:10.1117/1.JBO.20.11.110505

Imaging autofluorescence temporal signatures of the human ocular fundus in vivo

J Biomed Opt. 2015 Nov;20(11):110505. doi: 10.1117/1.JBO.20.11.110505.

Authors

Asael Papour¹, Zachary Taylor², Oscar Stafsudd¹, Irena Tsui³, Warren Grundfest²

Affiliations

¹ University of California, Los Angeles, Electrical Engineering Department, 56-125B Engineering, IV Building, 420 Westwood Plaza, Los Angeles, California 90095-1594, United States.
² University of California, Los Angeles, Department of Bioengineering, 410 Westwood Plaza, Room 5121, Engineering V, P.O. Box 951600, Los Angeles, California 90095-1600, United States.
³ University of California, Los Angeles, Stein Eye Institute and Doheny Eye Institute, 100 Stein Plaza, Los Angeles, California 90095-7000, United States.

PMID: 26590217
DOI: 10.1117/1.JBO.20.11.110505

Abstract

We demonstrate real-time in vivo fundus imaging capabilities of our fluorescence lifetime imaging technology for the first time. This implementation of lifetime imaging uses light emitting diodes to capture full-field images capable of showing direct tissue contrast without executing curve fitting or lifetime calculations. Preliminary results of fundus images are presented, investigating autofluorescence imaging potential of various retina biomarkers for early detection of macular diseases.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Equipment Design
Equipment Failure Analysis
Fluorescein Angiography / instrumentation*
Fundus Oculi
Humans
Image Enhancement / instrumentation*
In Vitro Techniques
Lighting / instrumentation*
Microscopy, Fluorescence / instrumentation*
Optical Imaging / instrumentation*
Reproducibility of Results
Retinoscopes*
Sensitivity and Specificity
Swine