Surface modification strategies on mesoporous silica nanoparticles for anti-biofouling zwitterionic film grafting

Yit Lung Khung; Dario Narducci

doi:10.1016/j.cis.2015.10.009

Surface modification strategies on mesoporous silica nanoparticles for anti-biofouling zwitterionic film grafting

Adv Colloid Interface Sci. 2015 Dec;226(Pt B):166-86. doi: 10.1016/j.cis.2015.10.009. Epub 2015 Oct 31.

Authors

Yit Lung Khung¹, Dario Narducci²

Affiliations

¹ Department of Materials Science, University of Milan-Bicocca, Via R. Cozzi 55, I-20125 Milan Italy; Institute of New Drug Development, China Medical University, No. 91 Hsueh-Shih Road, Taichung 404, Taiwan. Electronic address: yitlung.khung@mail.cmu.edu.tw.
² Department of Materials Science, University of Milan-Bicocca, Via R. Cozzi 55, I-20125 Milan Italy.

PMID: 26589704
DOI: 10.1016/j.cis.2015.10.009

Abstract

In the past decade, zwitterionic-based anti-biofouling layers had gained much focus as a serious alternative to traditional polyhydrophilic films such as PEG. In the area of assembling silica nanoparticles with stealth properties, the incorporation of zwitterionic surface film remains fairly new but considering that silica nanoparticles had been widely demonstrated as useful biointerfacing nanodevice, zwitterionic film grafting on silica nanoparticle holds much potential in the future. This review will discuss on the conceivable functional chemistry approaches, some of which are potentially suitable for the assembly of such stealth systems.

Keywords: Anti-biofouling; Silica nanoparticles; Zwitterionic films.

Publication types

Review

MeSH terms

Biofouling / prevention & control*
Nanoparticles / chemistry*
Particle Size
Porosity
Silicon Dioxide / chemistry*
Surface Properties

Substances

Silicon Dioxide