Adipose Tissue: Sanctuary for HIV/SIV Persistence and Replication

Trends Microbiol. 2015 Dec;23(12):748-750. doi: 10.1016/j.tim.2015.11.001. Epub 2015 Nov 14.

Abstract

This commentary highlights new findings from a recent study identifying adipose tissue as a potential HIV reservoir and a major site of inflammation during chronic human/simian immunodeficiency virus (HIV/SIV) infection. A concise discussion about upcoming challenges and new research avenues for reducing chronic adipose inflammation during HIV/SIV infection is presented.

Keywords: CD4/CD8 T-cell; HIV/SIV reservoir; adipose tissue; inflammation; macrophage.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adipose Tissue / immunology*
  • Adipose Tissue / pathology
  • Adipose Tissue / virology
  • Animals
  • CD4-Positive T-Lymphocytes / virology
  • CD8-Positive T-Lymphocytes / virology
  • HIV / genetics
  • HIV / immunology*
  • HIV Infections / immunology*
  • HIV Infections / virology
  • Humans
  • Inflammation / virology
  • Macaca mulatta / virology
  • Macrophages / virology
  • Simian Acquired Immunodeficiency Syndrome / immunology*
  • Simian Acquired Immunodeficiency Syndrome / virology
  • Simian Immunodeficiency Virus / genetics
  • Simian Immunodeficiency Virus / immunology*
  • Viral Load
  • Virus Replication