Lung specific X protein as a novel therapeutic target for lung cancer

Xiaohu Zheng; Zhigang Tian; Haiming Wei

doi:10.1080/2162402X.2015.1052931

Lung specific X protein as a novel therapeutic target for lung cancer

Oncoimmunology. 2015 Aug 17;4(12):e1052931. doi: 10.1080/2162402X.2015.1052931. eCollection 2015 Dec.

Authors

Xiaohu Zheng¹, Zhigang Tian¹, Haiming Wei¹

Affiliation

¹ Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease; School of Life Science and Medical Center; University of Science and Technology of China ; Hefei, China ; Hefei National Laboratory for Physical Sciences at Microscale; University of Science and Technology of China ; Hefei, China.

Abstract

The identification of novel therapeutic targets in lung cancer is an urgent challenge. We found lung-specific X protein (LunX) is overexpressed in lung cancer and promotes primary tumor growth and metastatic colonization. The antibody against LunX appears to be potentially applicable for therapeutic use in the future, given its efficacy in preclinical models.

Keywords: 14–3–3; LunX; antibody therapy; non-small-cell lung cancer; tumor growth and metastasis.