Facile microwave-assisted synthesis of benzimidazole scaffolds via Ugi-type three-component condensation (3CC) reactions

Mol Divers. 2016 May;20(2):575-80. doi: 10.1007/s11030-015-9646-7. Epub 2015 Nov 18.

Abstract

Two series of fused benzimidazoles were synthesized via a facile, one-pot procedure under microwave irradiation. This procedure generated the desired products in high yields and could provide a useful synthetic platform with potential applications in medicinal chemistry.

Keywords: Benzimidazole; Cyclization; Groebke–Blackburn reaction; Microwave irradiation; Multicomponent reactions (MCRs); Three-component condensation (3-CC).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / chemistry*
  • Chemistry Techniques, Synthetic
  • Cyanides / chemistry
  • Microwaves*
  • Pyridines / chemistry

Substances

  • Benzimidazoles
  • Cyanides
  • Pyridines
  • benzimidazole
  • pyridine