Preparation of novel stable antibacterial nanoparticles using hydroxyethylcellulose and application in paper

Dafu Wei; Yan Chen; Youwei Zhang

doi:10.1016/j.carbpol.2015.09.086

Preparation of novel stable antibacterial nanoparticles using hydroxyethylcellulose and application in paper

Carbohydr Polym. 2016 Jan 20:136:543-50. doi: 10.1016/j.carbpol.2015.09.086. Epub 2015 Sep 28.

Authors

Dafu Wei¹, Yan Chen², Youwei Zhang³

Affiliations

¹ Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
² State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
³ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. Electronic address: zhyw@dhu.edu.cn.

PMID: 26572386
DOI: 10.1016/j.carbpol.2015.09.086

Abstract

Taking advantage of the self-assembly between the components, novel stable antibacterial nanoparticles were efficiently fabricated via a facile one-step co-polymerization of acrylic acid (AA) and N,N'-methylenebisacrylamide (MBA) on a mixed aqueous solution of poly(hexamethylene guanidine hydrochloride) (PHMG) and hydroxyethylcellulose (HEC). The z-average hydrodynamic diameters of the nanoparticles ranged from 220 nm to 450 nm. The inner layer of the nanoparticles is composed of water-insoluble interpolymer complexes of PHMG and PAA networks, while the outer layer is composed of PHMG and HEC. The nanoparticles are stabilized by electrostatic interactions, hydrogen bonding interactions, and the chemical bonds. The nanoparticle solution remained stable in a wide pH range of 2.0-12.0 and at salt concentrations below 0.25 mol/L. The nanoparticles were incorporated into handsheets using a dipping treatment. The resulted handsheets exhibited excellent antimicrobial activities even after multiple water washing treatments. The nanoparticles are promising in fabricating paper, water-based coatings and textiles with permanent antibacterial activity.

Keywords: Acrylic acid (PubChem CID: 6581); Ammonium persulfate (PubChem CID: 62648); Antibacterial activity; Guanidine hydrochloride (PubChem CID: 5742); Hexamethylene diamine (PubChem CID: 16402); Hydrochloric acid (PubChem CID: 313); Hydroxyethylcellulose; N,N,N′,N′-tetramethylethylene diamine (PubChem CID: 8037); N,N′-methylenebisacrylamide (PubChem CID: 8041); Nanoparticles; Poly(hexamethylenediamine guanidine hydrochloride); Self-assembly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylamides / chemistry
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Cellulose / analogs & derivatives*
Cellulose / chemistry
Escherichia coli / drug effects
Guanidines / chemistry
Nanoparticles / chemistry*
Paper*

Substances

Acrylamides
Anti-Bacterial Agents
Guanidines
polyhexamethyleneguanidine
Cellulose
hydroxyethylcellulose
N,N'-methylenebisacrylamide