Recent advances in the biosynthesis of unusual polyketide synthase substrates

Lauren Ray; Bradley S Moore

doi:10.1039/c5np00112a

Recent advances in the biosynthesis of unusual polyketide synthase substrates

Nat Prod Rep. 2016 Feb;33(2):150-61. doi: 10.1039/c5np00112a.

Authors

Lauren Ray¹, Bradley S Moore²

Affiliations

¹ Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA. bsmoore@ucsd.edu.
² Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA. bsmoore@ucsd.edu and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093-0204, USA.

Abstract

This highlight provides an overview of recent advances in understanding the diversity of polyketide synthase (PKS) substrate building blocks. Substrates functioning as starter units and extender units contribute significantly to the chemical complexity and structural diversity exhibited by this class of natural products. This article complements and extends upon the current comprehensive reviews that have been published on these two topics (Moore and Hertweck, Nat. Prod. Rep., 2002, 19, 70; Chan et al., Nat. Prod. Rep., 2009, 1, 90; Wilson and Moore, Nat. Prod. Rep., 2012, 29, 72).

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Biological Products / chemistry
Biological Products / metabolism*
Humans
Molecular Structure
Peptide Synthases / classification
Peptide Synthases / metabolism*
Polyketides / chemistry
Polyketides / metabolism*
Substrate Specificity

Substances

Biological Products
Polyketides
Peptide Synthases
non-ribosomal peptide synthase

Abstract

Publication types

MeSH terms

Substances

Grants and funding