Increased production of reactive oxygen species has been implicated in the pathogenesis of congestive heart failure. However, emerging evidence suggests a role for reactive oxygen species in regulating various physiological cellular processes in the myocardium. The authors summarize the current understanding of involvement of reactive oxygen species in the regulation of cardiac contractility under physiological conditions.
Keywords: cardiac contractility; endothelin; endothelin-1; jelátvitel; reactive oxygen species; reaktívoxigén-származékok; signal transduction; szívizom-kontraktilitás; β-adrenerg-stimuláció; β-adrenergic stimulation.