Four New Flavonoids with α-Glucosidase Inhibitory Activities from Morus alba var. tatarica

Ya-Long Zhang; Jian-Guang Luo; Chuan-Xing Wan; Zhong-Bo Zhou; Ling-Yi Kong

doi:10.1002/cbdv.201500005

Four New Flavonoids with α-Glucosidase Inhibitory Activities from Morus alba var. tatarica

Chem Biodivers. 2015 Nov;12(11):1768-76. doi: 10.1002/cbdv.201500005.

Authors

Ya-Long Zhang¹, Jian-Guang Luo², Chuan-Xing Wan³, Zhong-Bo Zhou¹, Ling-Yi Kong⁴

Affiliations

¹ State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China, (phone/fax: +86-25-83271405).
² State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China, (phone/fax: +86-25-83271405). luojg99@163.com.
³ Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Group, Tarim University, Alaer 843300, P. R. China.
⁴ State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China, (phone/fax: +86-25-83271405). cpu_lykong@126.com.

PMID: 26567954
DOI: 10.1002/cbdv.201500005

Abstract

Four new flavonoids, mortatarins A-D (1-4, resp.), along with eight known flavonoids (5-12) were isolated from the root bark of Morus alba var. tatarica. Their structures were established on the basis of spectroscopic data analysis, and the absolute configuration of 4 was determined by analysis of its CD spectrum. All isolates were tested for inhibitory activities against α-glucosidase. Compounds 4, 7, and 8 exhibited a significant degree of inhibition with IC50 values of 5.0 ± 0.3, 7.5 ± 0.5, and 5.9 ± 0.2 μM, respectively.

Keywords: Flavonoids; Mortatarins A - D; Morus alba; α-Glucosidase.

MeSH terms

Dose-Response Relationship, Drug
Flavonoids / chemistry
Flavonoids / isolation & purification*
Flavonoids / pharmacology*
Glycoside Hydrolase Inhibitors / chemistry
Glycoside Hydrolase Inhibitors / isolation & purification*
Glycoside Hydrolase Inhibitors / pharmacology*
Humans
Molecular Conformation
Morus / chemistry*
Plant Bark / chemistry
Structure-Activity Relationship
alpha-Glucosidases / metabolism*

Substances

Flavonoids
Glycoside Hydrolase Inhibitors
alpha-Glucosidases