The Epigenetic Modifications of Genes Associated with Tuberculosis Susceptibility and Implications for Epi-Drugs

Crit Rev Eukaryot Gene Expr. 2015;25(4):349-62. doi: 10.1615/critreveukaryotgeneexpr.2015014334.

Abstract

Epigenetics of genes associated with tuberculosis susceptibility such as DNA methylation, posttranslational histone modifications, and non-coding RNA remain largely untapped field for better tuberculosis control. Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification. Our summary of these modifications provides fresh insights into the pathogenesis of tuberculosis and inspires targets discovery for host-derived therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cytokines / genetics
  • Epigenesis, Genetic*
  • Epistasis, Genetic
  • Genetic Predisposition to Disease*
  • Histone Code
  • Humans
  • Mutation
  • Mycobacterium tuberculosis / physiology*
  • RNA Interference
  • Tuberculosis / drug therapy
  • Tuberculosis / genetics*
  • Tuberculosis / immunology*
  • Tuberculosis / microbiology

Substances

  • Cytokines