NIR-Laser-Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors

Adv Mater. 2016 Jan 13;28(2):245-53. doi: 10.1002/adma.201502669. Epub 2015 Nov 9.

Abstract

In vivo MEO2 MA@MEO2 MA-co-OEGMA-CuS-DOX (G-CuS-DOX) nanocapsules increase the temperature of tumors from room temperature to 57 °C due to the photothermal effect under irradiation from a 915-nm laser. When the temperature exceeds 42 °C, photothermal therapy of G-CuS-DOX is switched on. Simultaneously, higher temperatures (>LCST, 42 °C) induce volume shrinkage of G-CuS-DOX in vivo, leading to the controllable release of the anticancer drug DOX. If the NIR laser is switched off, both therapy effects are interrupted immediately.

Keywords: NIR lasers; chemotherapy; photothermal therapy; smart nanocapsules; switches; tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / pharmacokinetics
  • Carcinoma, Hepatocellular / diagnostic imaging
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / secondary
  • Carcinoma, Hepatocellular / therapy*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Combined Modality Therapy
  • Doxorubicin / administration & dosage
  • Doxorubicin / pharmacokinetics
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Hyperthermia, Induced*
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / pathology
  • Liver Neoplasms / secondary
  • Liver Neoplasms / therapy*
  • Low-Level Light Therapy / methods*
  • Mice
  • Nanocapsules* / chemistry
  • Neoplasm Transplantation
  • Tumor Burden / drug effects
  • Tumor Burden / radiation effects
  • Water / chemistry

Substances

  • Antineoplastic Agents
  • Nanocapsules
  • Water
  • Doxorubicin