Abstract
In vivo MEO2 MA@MEO2 MA-co-OEGMA-CuS-DOX (G-CuS-DOX) nanocapsules increase the temperature of tumors from room temperature to 57 °C due to the photothermal effect under irradiation from a 915-nm laser. When the temperature exceeds 42 °C, photothermal therapy of G-CuS-DOX is switched on. Simultaneously, higher temperatures (>LCST, 42 °C) induce volume shrinkage of G-CuS-DOX in vivo, leading to the controllable release of the anticancer drug DOX. If the NIR laser is switched off, both therapy effects are interrupted immediately.
Keywords:
NIR lasers; chemotherapy; photothermal therapy; smart nanocapsules; switches; tumors.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / pharmacokinetics
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Carcinoma, Hepatocellular / diagnostic imaging
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Carcinoma, Hepatocellular / pathology
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Carcinoma, Hepatocellular / secondary
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Carcinoma, Hepatocellular / therapy*
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Cell Line, Tumor
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Combined Modality Therapy
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Doxorubicin / administration & dosage
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Doxorubicin / pharmacokinetics
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Humans
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Hydrophobic and Hydrophilic Interactions
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Hyperthermia, Induced*
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Liver Neoplasms / diagnostic imaging
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Liver Neoplasms / pathology
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Liver Neoplasms / secondary
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Liver Neoplasms / therapy*
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Low-Level Light Therapy / methods*
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Mice
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Nanocapsules* / chemistry
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Neoplasm Transplantation
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Tumor Burden / drug effects
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Tumor Burden / radiation effects
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Water / chemistry
Substances
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Antineoplastic Agents
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Nanocapsules
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Water
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Doxorubicin