A new way to target p53-defective colorectal cancer

Future Oncol. 2015;11(23):3101-4. doi: 10.2217/fon.15.223. Epub 2015 Nov 9.
No abstract available

Keywords: POLR2A; colorectal cancer; hemizygous loss; p53; tumor suppressor gene; α-amanitin.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms / drug therapy*
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / metabolism
  • Genomics
  • Hemizygote
  • Humans
  • Molecular Targeted Therapy*
  • RNA Polymerase II / antagonists & inhibitors
  • RNA Polymerase II / chemistry
  • RNA Polymerase II / genetics
  • RNA Polymerase II / metabolism
  • Tumor Suppressor Protein p53 / deficiency*

Substances

  • Tumor Suppressor Protein p53
  • RNA Polymerase II