Optimal Placement of Irradiation Sources in the Planning of Radiotherapy: Mathematical Models and Methods of Solving

Comput Math Methods Med. 2015:2015:142987. doi: 10.1155/2015/142987. Epub 2015 Oct 12.

Abstract

This paper proposes and analyses a mathematical model for the problem of distribution of a finite number of irradiation sources during radiotherapy in continuous environments to maximize the minimal cumulative effects. A new algorithm based on nondifferentiable optimization techniques has been developed to solve this problem.

MeSH terms

  • Algorithms*
  • Computational Biology
  • Computer Simulation
  • Humans
  • Mathematical Concepts
  • Models, Biological
  • Neoplasms / radiotherapy
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Radiotherapy Planning, Computer-Assisted / statistics & numerical data