Diabetes and osteoporosis: Action of gastrointestinal hormones on the bone

Rev Clin Esp (Barc). 2013 Aug-Sep;213(6):293-7. doi: 10.1016/j.rce.2013.01.014. Epub 2013 Mar 29.
[Article in English, Spanish]

Abstract

A 62-year-old woman consulted for evaluation of treatment for her type 2 diabetes diagnosed four years ago. He had been received treatment with metformin 850mg twice, with no chronic associated complications. She had hypertension and dyslipidemia. She was being treated with candesartan/hydrochlorothiazide 32/12.5mg and atorvastatin 40mg. Her weight was 92kg and height 162cm (BMI, 35.1kg/m(2)). The last analysis showed fasting glucose 168mg/dl and glycated hemoglobin 7.5%, Microalbuminuria was negative. Blood pressure and lipid profile were within the therapeutic range. Two years ago she suffered a nontraumatic Colle's fracture in her left arm for which she was taking a daily calcium and vitamin D supplement and weekly alendronate. In summary, this is an obese female patient with type 2 diabetes mellitus and inadequate metabolic control, She also has a history of fragility fracture. How should this patient be evaluated and treated?

Keywords: Diabetes mellitus tipo 2; Gastrointestinal hormones; Hormonas gastrointestinales; Osteoporosis; Type 2 diabetes mellitus.