Synthesis at the Speed of Codons

Kristin S Koutmou; Aditya Radhakrishnan; Rachel Green

doi:10.1016/j.tibs.2015.10.005

Synthesis at the Speed of Codons

Trends Biochem Sci. 2015 Dec;40(12):717-718. doi: 10.1016/j.tibs.2015.10.005. Epub 2015 Oct 31.

Authors

Kristin S Koutmou¹, Aditya Radhakrishnan¹, Rachel Green²

Affiliations

¹ Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
² Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: ragreen@jhmi.edu.

PMID: 26526516
DOI: 10.1016/j.tibs.2015.10.005

Abstract

The possibility that different mRNA sequences encoding identical peptides are translated dissimilarly has long been of great interest. Recent work by Yu and co-workers provides striking evidence that mRNA sequences influence the rate of protein synthesis, and lends support to the emerging idea that mRNA sequence informs protein folding.

Publication types

Comment

MeSH terms

Animals
Codon / genetics*
Peptide Chain Elongation, Translational*
Protein Folding*

Substances

Codon

Grants and funding

R37 GM059425/GM/NIGMS NIH HHS/United States