Synthesis and antiproliferativeactivity of new vinca alkaloids containing an α,β-unsaturated aromatic side chain

Quoc Anh Ngo; Le Anh Nguyen; Ngoc Binh Vo; Thuy Hang Nguyen; Fanny Roussi; The Hung Nguyen; Van Tuyen Nguyen

doi:10.1016/j.bmcl.2015.10.040

Synthesis and antiproliferativeactivity of new vinca alkaloids containing an α,β-unsaturated aromatic side chain

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5597-600. doi: 10.1016/j.bmcl.2015.10.040. Epub 2015 Oct 23.

Authors

Quoc Anh Ngo¹, Le Anh Nguyen², Ngoc Binh Vo², Thuy Hang Nguyen², Fanny Roussi³, The Hung Nguyen⁴, Van Tuyen Nguyen²

Affiliations

¹ Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi, Viet Nam. Electronic address: ngoquocanh74m@yahoo.com.
² Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi, Viet Nam.
³ Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, UPR 2301 du CNRS, Université Paris Sud, 1 avenue de la terrasse, 91198 Gif sur Yvette Cedex, France.
⁴ Ministry of Science and Technology, Viet Nam.

PMID: 26522953
DOI: 10.1016/j.bmcl.2015.10.040

Abstract

A new series of vinca-alkaloids derivatives containing various α,β-unsaturated aromatic side chains was synthesized. Four new vinca-alkaloids derivatives showed selective cytotoxicities against KB tumor cell lines with IC50 value below 0.1 μM, thus comparable with vinblastine.

Keywords: Cytotoxicity; Sarcodictyins; Tubulin; Vinca alkaloids.

MeSH terms

Antineoplastic Agents, Phytogenic / chemical synthesis*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / therapeutic use*
Cell Line, Tumor
Humans
Inhibitory Concentration 50
Molecular Structure
Neoplasms / drug therapy*
Vinblastine / chemistry
Vinblastine / therapeutic use*
Vinca Alkaloids / chemistry

Substances

Antineoplastic Agents, Phytogenic
Vinca Alkaloids
Vinblastine