ADAMs family and relatives in cardiovascular physiology and pathology

Pu Zhang; Mengcheng Shen; Carlos Fernandez-Patron; Zamaneh Kassiri

doi:10.1016/j.yjmcc.2015.10.031

ADAMs family and relatives in cardiovascular physiology and pathology

J Mol Cell Cardiol. 2016 Apr:93:186-99. doi: 10.1016/j.yjmcc.2015.10.031. Epub 2015 Oct 29.

Authors

Pu Zhang¹, Mengcheng Shen¹, Carlos Fernandez-Patron², Zamaneh Kassiri³

Affiliations

¹ Department of Physiology, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
² Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
³ Department of Physiology, University of Alberta, Edmonton, Alberta, Canada; Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada. Electronic address: z.kassiri@ualberta.ca.

PMID: 26522853
DOI: 10.1016/j.yjmcc.2015.10.031

Abstract

A disintegrin and metalloproteinases (ADAMs) are a family of membrane-bound proteases. ADAM-TSs (ADAMs with thrombospondin domains) are a close relative of ADAMs that are present in soluble form in the extracellular space. Dysregulated production or function of these enzymes has been associated with pathologies such as cancer, asthma, Alzheimer's and cardiovascular diseases. ADAMs contribute to angiogenesis, hypertrophy and apoptosis in a stimulus- and cell type-dependent manner. Among the ADAMs identified so far (34 in mouse, 21 in human), ADAMs 8, 9, 10, 12, 17 and 19 have been shown to be involved in cardiovascular development or cardiomyopathies; and among the 19 ADAM-TSs, ADAM-TS1, 5, 7 and 9 are important in development of the cardiovascular system, while ADAM-TS13 can contribute to vascular disorders. Meanwhile, there remain a number of ADAMs and ADAM-TSs whose function in the cardiovascular system has not been yet explored. The current knowledge about the role of ADAMs and ADAM-TSs in the cardiovascular pathologies is still quite limited. The most detailed studies have been performed in other cell types (e.g. cancer cells) and organs (nervous system) which can provide valuable insight into the potential functions of ADAMs and ADAM-TSs, their mechanism of action and therapeutic potentials in cardiomyopathies. Here, we review what is currently known about the structure and function of ADAMs and ADAM-TSs, and their roles in development, physiology and pathology of the cardiovascular system.

Keywords: ADAM-TS; ADAMs; Heart disease; Remodeling.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

ADAM Proteins / chemistry
ADAM Proteins / genetics*
ADAM Proteins / metabolism*
Animals
Cardiovascular Diseases / etiology*
Cardiovascular Diseases / metabolism*
Cardiovascular Physiological Phenomena*
Disease Models, Animal
Gene Expression Regulation
Humans
Multigene Family
Mutation
Organogenesis / genetics
Polymorphism, Genetic
Protein Binding
Protein Interaction Domains and Motifs
Substrate Specificity

Substances

ADAM Proteins