An Individual-Centered Framework For Unravelling Genotype-Phenotype Interactions

Michel Baguette; Delphine Legrand; Virginie M Stevens

doi:10.1016/j.tree.2015.10.003

An Individual-Centered Framework For Unravelling Genotype-Phenotype Interactions

Trends Ecol Evol. 2015 Dec;30(12):709-711. doi: 10.1016/j.tree.2015.10.003. Epub 2015 Oct 29.

Authors

Michel Baguette¹, Delphine Legrand², Virginie M Stevens³

Affiliations

¹ Station d'Ecologie Expérimentale, CNRS USR 2936, F-09200 Moulis, France; Muséum National d'Histoire Naturelle, UMR 7205 ISYEB, F-75005, Paris, France. Electronic address: baguette@mnhn.fr.
² Station d'Ecologie Expérimentale, CNRS USR 2936, F-09200 Moulis, France; Earth and Life Institute, UCL BRC, B-1348, Louvain-la-Neuve, Belgium.
³ Station d'Ecologie Expérimentale, CNRS USR 2936, F-09200 Moulis, France.

PMID: 26522730
DOI: 10.1016/j.tree.2015.10.003

Abstract

A new framework in which the multiple levels of molecular variations contribute to phenotypic variations in a complex, nonlinear and interactive way, challenges the hierarchical nature of the relationships between the genotypic and phenotypic spaces. This individual-centered framework provides new insights on the evolutionary mechanisms involved in the production of phenotypes. We propose to move this research agenda forward by combining selection experiments and functional genetics.

Keywords: Genome; epigenome; molecular pedigree of evolutionary changes; phenome; proteome; syndrome.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Data Interpretation, Statistical*
Genetic Variation*
Genotype*
Humans
Inheritance Patterns / physiology*
Models, Biological*
Phenotype*
Systems Biology / methods*