Low miR-19b-1-5p expression in isolated platelets after aspirin use is related to aspirin insensitivity

M G M Kok; C Mandolini; P D Moerland; M W J de Ronde; B M Sondermeijer; A Halliani; R Nieuwland; F Cipollone; E E Creemers; J C M Meijers; S J Pinto-Sietsma

doi:10.1016/j.ijcard.2015.10.098

Low miR-19b-1-5p expression in isolated platelets after aspirin use is related to aspirin insensitivity

Int J Cardiol. 2016 Jan 15:203:262-3. doi: 10.1016/j.ijcard.2015.10.098. Epub 2015 Oct 23.

Authors

M G M Kok¹, C Mandolini², P D Moerland³, M W J de Ronde¹, B M Sondermeijer⁴, A Halliani⁵, R Nieuwland⁶, F Cipollone⁷, E E Creemers⁵, J C M Meijers⁸, S J Pinto-Sietsma⁹

Affiliations

¹ Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
² Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Hypertension and Dyslipidemia, Geriatric Clinic and European Center on Atherosclerosis, G. D'Annunzio University, Chieti, Italy.
³ Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
⁴ Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
⁵ Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
⁶ Department of Clinical Chemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
⁷ Department of Hypertension and Dyslipidemia, Geriatric Clinic and European Center on Atherosclerosis, G. D'Annunzio University, Chieti, Italy.
⁸ Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Plasma Proteins, Sanquin, Amsterdam, The Netherlands.
⁹ Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: S.J.Pinto@amc.uva.nl.

PMID: 26519680
DOI: 10.1016/j.ijcard.2015.10.098

No abstract available

Keywords: Antiplatelet agents; Aspirin resistance; Prevention; miRNA.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Anticholesteremic Agents / administration & dosage
Aspirin / administration & dosage*
Blood Platelets / drug effects
Blood Platelets / metabolism*
Coronary Artery Disease / blood
Coronary Artery Disease / drug therapy
Coronary Artery Disease / genetics
Drug Resistance
Humans
Indomethacin / administration & dosage
Male
MicroRNAs / biosynthesis
MicroRNAs / blood*
MicroRNAs / genetics
Middle Aged
Platelet Aggregation Inhibitors / administration & dosage*
RNA / blood
RNA / genetics
Simvastatin / administration & dosage

Substances

Anti-Inflammatory Agents, Non-Steroidal
Anticholesteremic Agents
MIRN19 microRNA, human
MicroRNAs
Platelet Aggregation Inhibitors
RNA
Simvastatin
Aspirin
Indomethacin