An open randomized controlled clinical trial to evaluate ridge preservation and repair using SocketKAP(™) and SocketKAGE(™) : part 2 - three-dimensional alveolar bone volumetric analysis of CBCT imaging

Clin Oral Implants Res. 2016 Jun;27(6):631-9. doi: 10.1111/clr.12687. Epub 2015 Oct 31.

Abstract

Objectives: The aims of this study were (i) to evaluate the efficacy of ridge preservation and repair procedures involving the application of SocketKAP(™) and SocketKAGE(™) devices following tooth removal and (ii) to evaluate alveolar bone volumetric changes at 6 months post-extraction in intact sockets or those with facial wall dehiscence defects using 3-dimensional pre- and postoperative CBCT data.

Materials and methods: Thirty-six patients required 61 teeth extracted. Five cohorts were established: Group A: Intact Socket Negative Control Group B: Intact Socket + SocketKAP(™) Group C: Intact Socket Filled with Anorganic Bovine Bone Mineral (ABBM) + SocketKAP(™) Group D: Facial Dehiscence Socket Negative Control Group E: Facial Dehiscence Socket Filled with ABBM + SocketKAP(™) + SocketKAGE(™) . Preoperative CBCT scans were obtained followed by digital subtraction of the test teeth. At 6 months post-extraction, another CBCT scan was obtained. The pre- and postoperative scans were then superimposed, allowing highly accurate quantitative determination of the 3D volumetric alveolar bone volume changes from baseline through 6 months.

Results: Significant volumetric bone loss occurred in all sockets, localized mainly in the 0-3 mm zone apical to the ridge crest. For intact sockets, SocketKAP(™) + ABBM treatment led to a statistically significant greater percentage of remaining mineralized tissue volume when compared to negative control group. A significant difference favoring SocketKAP(™) + SocketKAGE(™) + ABBM treatment was observed for sockets with facial dehiscence defects compared to the negative control group.

Conclusions: SocketKAP(™) , with ABBM, appears effective in limiting post-extraction volumetric bone loss in intact sockets, while SocketKAP(™) + SocketKAGE + ABBM appears effective in limiting post-extraction bone loss in sockets with dehiscence defects.

Keywords: CBCT; alveolar bone grafting; bone substitute; tooth extraction.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Absorbable Implants
  • Adult
  • Alveolar Bone Loss / diagnostic imaging*
  • Alveolar Bone Loss / prevention & control*
  • Alveolar Ridge Augmentation / methods*
  • Animals
  • Cattle
  • Cone-Beam Computed Tomography / methods*
  • Dental Prosthesis Design
  • Dental Prosthesis*
  • Female
  • Humans
  • Imaging, Three-Dimensional / methods*
  • Male
  • Middle Aged
  • Minerals
  • Polypropylenes
  • Prospective Studies
  • Tooth Extraction
  • Tooth Socket / surgery*

Substances

  • Bio-Oss
  • Minerals
  • Polypropylenes