Nonconventional three-finger toxin BMLCL from krait Bungarus multicinctus venom with high affinity interacts with nicotinic acetylcholine receptors

Dokl Biochem Biophys. 2015:464:294-7. doi: 10.1134/S1607672915050099. Epub 2015 Oct 31.

Abstract

Nonconventional three-finger toxin BMLCL was isolated from B. multicinctus venom, and its interaction with different subtypes of nicotinic acetylcholine receptor (nAChR) was studied. It was found that BMLCL is able to interact with high efficiency with both α7 and muscle type nAChRs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / pharmacology
  • Amino Acid Sequence
  • Animals
  • Aplysia
  • Bungarotoxins / chemistry
  • Bungarotoxins / isolation & purification
  • Bungarotoxins / metabolism*
  • Bungarotoxins / pharmacology*
  • Bungarus
  • Cholinergic Agents / chemistry
  • Cholinergic Agents / isolation & purification
  • Cholinergic Agents / metabolism
  • Cholinergic Agents / pharmacology*
  • Cobra Neurotoxin Proteins / pharmacology
  • Humans
  • Lymnaea
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Molecular Sequence Data
  • Oocytes
  • Rats
  • Receptors, Nicotinic / metabolism*
  • Reptilian Proteins / chemistry
  • Reptilian Proteins / isolation & purification
  • Reptilian Proteins / metabolism*
  • Reptilian Proteins / pharmacology*
  • Sequence Homology, Amino Acid
  • Xenopus

Substances

  • BMLCL protein, Bungarus multicinctus multicinctus
  • Bungarotoxins
  • Cholinergic Agents
  • Cobra Neurotoxin Proteins
  • Receptors, Nicotinic
  • Reptilian Proteins
  • alpha-cobratoxin
  • Acetylcholine