Tribbles in inflammation

Biochem Soc Trans. 2015 Oct;43(5):1069-74. doi: 10.1042/BST20150095.

Abstract

Inflammation is part of the physiological innate immune response to invading pathogens and tissue injury. However, unresolved inflammation leads to human disease. The tribbles (TRIB) family of pseudokinase proteins has been shown to modulate key inflammatory signalling pathways, including the MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinase) networks. This review summarizes our current knowledge on TRIBs in the context of inflammation, both at the level of molecular mechanisms and in disease development.

Keywords: chronic inflammation; disease; mitogen-activated protein kinase (MAPK); tribbles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Cell Cycle Proteins / metabolism*
  • Humans
  • Inflammation / metabolism*
  • Inflammation / pathology
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Models, Biological
  • Protein Serine-Threonine Kinases / antagonists & inhibitors*
  • Protein Serine-Threonine Kinases / metabolism
  • Repressor Proteins / metabolism*
  • Signal Transduction*

Substances

  • Cell Cycle Proteins
  • Intracellular Signaling Peptides and Proteins
  • Repressor Proteins
  • TRIB1 protein, human
  • TRIB3 protein, human
  • Protein Serine-Threonine Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • TRIB2 protein, human