A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines

Ronald Grigg; Elghareeb E Elboray; Sunisa Akkarasamiyo; Nutthawat Chuanopparat; H Ali Dondas; Hussien H Abbas-Temirek; Colin W G Fishwick; Moustafa F Aly; Boonsong Kongkathip; Ngampong Kongkathip

doi:10.1039/c5cc07526b

A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines

Chem Commun (Camb). 2016 Jan 4;52(1):164-6. doi: 10.1039/c5cc07526b.

Affiliations

¹ School of Chemistry, University of Leeds, Leeds, LS6 9JT, UK. r.grigg@leeds.ac.uk c.w.g.fishwick@leeds.ac.uk.
² School of Chemistry, University of Leeds, Leeds, LS6 9JT, UK. r.grigg@leeds.ac.uk c.w.g.fishwick@leeds.ac.uk and Department of Chemistry, Faculty of Science at Qena, South Valley University, Qena, Egypt.
³ School of Chemistry, University of Leeds, Leeds, LS6 9JT, UK. r.grigg@leeds.ac.uk c.w.g.fishwick@leeds.ac.uk and Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
⁴ Department of Chemistry, Faculty of Pharmacy, Mersin University, 33342, Mersin, Turkey.
⁵ Department of Chemistry, Faculty of Science at Qena, South Valley University, Qena, Egypt.
⁶ Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.

PMID: 26507255
DOI: 10.1039/c5cc07526b

Abstract

Palladium catalysed three component cascade process, involving coupling of 2-iodobenzoates, -benzaldehydes, or acetophenones with substituted allenes and ammonium tartrate as an ammonium surrogate, provides a novel and facile route to substituted functionalised isoquinolinones and isoquinolines in good yields.

Publication types

Research Support, Non-U.S. Gov't