A novel isocoumarin with anti-influenza virus activity from Strobilanthes cusia

Fitoterapia. 2015 Dec:107:60-62. doi: 10.1016/j.fitote.2015.10.009. Epub 2015 Oct 23.

Abstract

Strobilanthes A (1), a novel isocoumarin with an unusual tetrahydro-4H-pyran-4-one moiety fused isocoumarin core skeleton, together with a known compound (2) was isolated from Strobilanthes cusia. Its chemical structures were elucidated by 2D NMR spectroscopy, mass spectrometry and single-crystal X-ray diffraction analysis. The biosynthetic pathway of 1 could be supposed to be originally derived from 3-methylisocoumarin, a product of AA-MA pathway. Both of two compounds displayed anti-influenza virus activity in vitro.

Keywords: Anti-influenza virus activity; Novel isocoumarin; Strobilanthes cusia; Unprecedented skeleton.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acanthaceae / chemistry*
  • Antiviral Agents / chemistry*
  • Antiviral Agents / isolation & purification
  • Isocoumarins / chemistry*
  • Isocoumarins / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Orthomyxoviridae / drug effects*
  • Plant Roots / chemistry
  • X-Ray Diffraction

Substances

  • Antiviral Agents
  • Isocoumarins
  • strobilanthes A