An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels

Donatus O Onwuli; Pedro Beltran-Alvarez

doi:10.1007/s00726-015-2122-y

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels

Amino Acids. 2016 Mar;48(3):641-651. doi: 10.1007/s00726-015-2122-y. Epub 2015 Oct 27.

Authors

Donatus O Onwuli¹, Pedro Beltran-Alvarez²

Affiliations

¹ School of Biological, Biomedical and Environmental Sciences, University of Hull, Hardy Building Cottingham Road, Hull, HU6 7RX, UK.
² School of Biological, Biomedical and Environmental Sciences, University of Hull, Hardy Building Cottingham Road, Hull, HU6 7RX, UK. p.beltran-alvarez@hull.ac.uk.

Abstract

Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (NaV1.1), SCN2A (NaV1.2), SCN3A (NaV1.3) and SCN8A (NaV1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.

Keywords: Alternative splicing; Post-translational modification; Regulation; Transcription factor; Voltage-gated sodium channel.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain / metabolism*
Humans
Protein Processing, Post-Translational*
Transcription, Genetic*
Voltage-Gated Sodium Channels / genetics*
Voltage-Gated Sodium Channels / metabolism

Substances

Voltage-Gated Sodium Channels