Abstract
Novel esters of non steroidal anti-inflammatory drugs, α-lipoic acid and indol-3-acetic acid with cinnamyl alcohol were synthesised by a straightforward method and at high yields (60-98%). They reduced acute inflammation more than the parent acids and are potent inhibitors of soybean lipoxygenase. Selected structures decreased plasma lipidemic indices in Triton-induced hyperlipidemia to rats. Therefore, the synthesised compounds may add to the current knowledge about agents acting against various inflammatory disorders.
Keywords:
Cinnamyl esters; Dyslipidemia; Inflammation; Lipoxygenase inhibition; Non steroidal anti-inflammatory drugs.
Copyright © 2015 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Carrageenan
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Cinnamates / chemical synthesis
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Cinnamates / pharmacology*
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Cinnamates / therapeutic use
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Edema / chemically induced
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Edema / drug therapy
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Esters
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Glycine max
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Hyperlipidemias / chemically induced
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Hyperlipidemias / drug therapy
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Indoleacetic Acids / chemistry
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Lipoxygenase Inhibitors / chemical synthesis
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Lipoxygenase Inhibitors / pharmacology*
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Lipoxygenase Inhibitors / therapeutic use
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Polyethylene Glycols
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Propanols / chemistry*
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Propionates / chemical synthesis
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Propionates / pharmacology*
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Propionates / therapeutic use
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Rats
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Thioctic Acid / chemistry
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cinnamates
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Esters
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Indoleacetic Acids
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Lipoxygenase Inhibitors
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Propanols
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Propionates
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cinnamyl 2-(4-isobutylphenyl)propanoate
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Polyethylene Glycols
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indoleacetic acid
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Thioctic Acid
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Carrageenan
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cinnamyl alcohol
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tyloxapol