Distribution and health risk assessment of organochlorine pesticides (OCPs) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCPs in tongue

Abdallah Fikry A Mahmoud; Yoshinori Ikenaka; Yared B Yohannes; Wageh S Darwish; Elsaid A Eldaly; Alaa Eldin M A Morshdy; Shouta M M Nakayama; Hazuki Mizukawa; Mayumi Ishizuka

doi:10.1016/j.chemosphere.2015.10.016

Distribution and health risk assessment of organochlorine pesticides (OCPs) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCPs in tongue

Chemosphere. 2016 Feb:144:1365-71. doi: 10.1016/j.chemosphere.2015.10.016. Epub 2015 Oct 23.

Authors

Abdallah Fikry A Mahmoud¹, Yoshinori Ikenaka², Yared B Yohannes³, Wageh S Darwish⁴, Elsaid A Eldaly⁴, Alaa Eldin M A Morshdy⁴, Shouta M M Nakayama³, Hazuki Mizukawa⁵, Mayumi Ishizuka⁶

Affiliations

¹ Food Control Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.
² Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan; Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa.
³ Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.
⁴ Food Control Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.
⁵ Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, N18, W9, Kita-ku, Sapporo, 060-0818, Japan.
⁶ Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan. Electronic address: ishizum@vetmed.hokudai.ac.jp.

PMID: 26492422
DOI: 10.1016/j.chemosphere.2015.10.016

Abstract

Food consumption is an important route of human exposure to organochlorine pesticides (OCPs). In order to assess the potential human health risks associated with OCPs, edible cattle tissues (liver, kidney and tongue) were collected from three slaughter houses in Mansoura, Zagazig and Ismailia cities, Egypt. Levels of 22 OCPs such as hexachlorocyclohexanes (HCHs), dichlorodiphenyltrichloroethanes (DDTs), aldrin, dieldrin and endrin (Drins), chlordanes (CHLs), heptachlors (HPTs) and hexachlorobenzene (HCB) residues were investigated. Among the investigated OCPs, HCHs represented the most dominant group with high proportions of γ-HCH isomer (53-91% of total HCHs). Mansoura city had the highest OCPs contamination load ranged from 0.1 to 2827 ng g(-1) lw (lipid weight). Surprisingly, tongue samples collected from Mansoura showed the highest concentration of HCHs (448 ng g(-1) lw) in comparison to liver (152 ng g(-1) lw) and kidney (266 ng g(-1) lw). Generally, contamination pattern of OCPs was in the order of HCHs > Drins > CHLs > DDTs ≅ HCB and HPTs. Estimated daily intakes (EDIs) through dietary consumption of cattle tissues were lower than the recommended acceptable daily intakes (ADIs) established by FAO/WHO. However, the hazard ratios (HRs) based on cancer risk were greater than 1.0 for HCHs based on the average and 95th centile concentrations, indicating carcinogenic effects to consumers through cattle tissues consumption.

Keywords: Egypt; Kidney; Liver; Organochlorine pesticides; Risk assessment; Tongue.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldrin / analysis
Animals
Cattle
Chlordan / analysis
Dieldrin / analysis
Egypt
Environmental Monitoring / methods*
Food Contamination / analysis*
Hexachlorobenzene / analysis
Hexachlorocyclohexane / analysis
Humans
Hydrocarbons, Chlorinated / analysis*
Meat / analysis*
Pesticide Residues / analysis*
Risk Assessment

Substances

Hydrocarbons, Chlorinated
Pesticide Residues
Chlordan
Hexachlorobenzene
Hexachlorocyclohexane
Dieldrin
Aldrin