EAST Organizes Drosophila Insulator Proteins in the Interchromosomal Nuclear Compartment and Modulates CP190 Binding to Chromatin

PLoS One. 2015 Oct 21;10(10):e0140991. doi: 10.1371/journal.pone.0140991. eCollection 2015.

Abstract

Recent data suggest that insulators organize chromatin architecture in the nucleus. The best studied Drosophila insulator proteins, dCTCF (a homolog of the vertebrate insulator protein CTCF) and Su(Hw), are DNA-binding zinc finger proteins. Different isoforms of the BTB-containing protein Mod(mdg4) interact with Su(Hw) and dCTCF. The CP190 protein is a cofactor for the dCTCF and Su(Hw) insulators. CP190 is required for the functional activity of insulator proteins and is involved in the aggregation of the insulator proteins into specific structures named nuclear speckles. Here, we have shown that the nuclear distribution of CP190 is dependent on the level of EAST protein, an essential component of the interchromatin compartment. EAST interacts with CP190 and Mod(mdg4)-67.2 proteins in vitro and in vivo. Over-expression of EAST in S2 cells leads to an extrusion of the CP190 from the insulator bodies containing Su(Hw), Mod(mdg4)-67.2, and dCTCF. In consistent with the role of the insulator bodies in assembly of protein complexes, EAST over-expression led to a striking decrease of the CP190 binding with the dCTCF and Su(Hw) dependent insulators and promoters. These results suggest that EAST is involved in the regulation of CP190 nuclear localization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • Chromatin / metabolism*
  • DNA-Binding Proteins / metabolism
  • Drosophila / genetics*
  • Drosophila / metabolism*
  • Drosophila Proteins / metabolism*
  • Insulator Elements / genetics*
  • Microtubule-Associated Proteins / metabolism*
  • Nuclear Proteins / metabolism*
  • Promoter Regions, Genetic / genetics
  • Protein Binding / physiology
  • Transcription Factors / metabolism

Substances

  • CP190 protein, Drosophila
  • Chromatin
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Microtubule-Associated Proteins
  • Nuclear Proteins
  • Transcription Factors

Grants and funding

This study was supported by the Russian Science Foundation (http://www. rscf.ru) (project №14-14-01067). Experiments were performed using the equipment of IGB RAS facilities supported by the Ministry of Science and Education of the Russian Federation [grant no. 16.552.11.7067].