Use of Daptomycin in Critically Ill Children With Bloodstream Infections and Complicated Skin and Soft-tissue Infections

Pediatr Infect Dis J. 2016 Feb;35(2):180-2. doi: 10.1097/INF.0000000000000962.

Abstract

We report our clinical experience with the use of daptomycin, administered in the dosage of 8 mg/kg/d in 3 minutes, in treating 12 critically ill children younger than 12 years, with bloodstream infections (n = 9) and complicated skin and soft-tissue infections (n = 3). Mean treatment duration was 14 ± 5 days; microbiologic eradication was achieved in all patients, and no drug related adverse events occurred.

Publication types

  • Observational Study

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Child
  • Child, Preschool
  • Critical Illness*
  • Daptomycin / administration & dosage*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Infusions, Intravenous
  • Male
  • Prospective Studies
  • Sepsis / drug therapy*
  • Skin Diseases, Bacterial / drug therapy*
  • Soft Tissue Infections / drug therapy*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Daptomycin