Unique electrocatalytic activity of a nucleic acid-mimicking coordination polymer for the sensitive detection of coenzyme A and histone acetyltransferase activity

Yufang Hu; Siyu Chen; Yitao Han; Hongjun Chen; Qin Wang; Zhou Nie; Yan Huang; Shouzhuo Yao

doi:10.1039/c5cc06593c

Unique electrocatalytic activity of a nucleic acid-mimicking coordination polymer for the sensitive detection of coenzyme A and histone acetyltransferase activity

Chem Commun (Camb). 2015 Dec 25;51(99):17611-4. doi: 10.1039/c5cc06593c.

Authors

Yufang Hu¹, Siyu Chen¹, Yitao Han¹, Hongjun Chen¹, Qin Wang¹, Zhou Nie¹, Yan Huang¹, Shouzhuo Yao¹

Affiliation

¹ State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China. niezhou.hnu@gmail.com.

PMID: 26483158
DOI: 10.1039/c5cc06593c

Abstract

A nucleic acid-mimicking CoA-Ag(I) coordination polymer (CP) was in situ prepared and its unique electrocatalytic activity to H2O2 reduction was discovered. Based on it, a novel, label-free electrochemical sensor has been developed for the sensitive detection of coenzyme A (CoA) and histone acetyltransferase (HAT) activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Coenzyme A / analysis*
Electrochemistry*
Histone Acetyltransferases / metabolism*
Limit of Detection
Microscopy, Atomic Force
Nucleic Acids / chemistry*
Polymers / chemistry*

Substances

Nucleic Acids
Polymers
Histone Acetyltransferases
Coenzyme A