Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study

Akanksha Upadhyaya; Robert A Smith; Diego Chacon-Cortes; Gwladys Revêchon; Claire Bellis; Rod A Lea; Larisa M Haupt; Suzanne K Chambers; Philippa H Youl; Lyn R Griffiths

doi:10.1016/j.gene.2015.10.019

Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study

Gene. 2016 Jan 15;576(1 Pt 2):256-60. doi: 10.1016/j.gene.2015.10.019. Epub 2015 Oct 18.

Affiliations

¹ Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia; Griffith Health Institute, Griffith University, Queensland, Australia.
² Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.
³ Griffith Health Institute, Griffith University, Queensland, Australia; Cancer Council Queensland, Brisbane, Queensland, Australia; The Prostate Cancer Foundation of Australia, New South Wales, Australia; Health and Wellness Institute, Edith Cowan University, Western Australia, Australia; Centre for Clinical Research, University of Queensland, Queensland, Australia.
⁴ Griffith Health Institute, Griffith University, Queensland, Australia; Cancer Council Queensland, Brisbane, Queensland, Australia; School of Public Health, Queensland University of Technology, Queensland, Australia.
⁵ Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia; Griffith Health Institute, Griffith University, Queensland, Australia. Electronic address: lyn.griffiths@qut.edu.au.

PMID: 26476291
DOI: 10.1016/j.gene.2015.10.019

Abstract

Background: Breast cancer (BC) is primarily considered a genetic disorder with a complex interplay of factors including age, gender, ethnicity, family history, personal history and lifestyle with associated hormonal and non-hormonal risk factors. The SNP rs2910164 in miR146a (a G to C polymorphism) was previously associated with increased risk of BC in cases with at least a single copy of the C allele in breast cancer, though results in other cancers and populations have shown significant variation.

Methods: In this study, we examined this SNP in an Australian sporadic breast cancer population of 160 cases and matched controls, with a replicate population of 403 breast cancer cases using High Resolution Melting.

Results: Our analysis indicated that the rs2910164 polymorphism is associated with breast cancer risk in both primary and replicate populations (p=0.03 and 0.0013, respectively). In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40-2.23).

Conclusions: The microRNA miR146a has a potential role in the development of breast cancer and the effects of its SNPs require further inquiry to determine the nature of their influence on breast tissue and cancer.

Keywords: BRCA; Breast cancer; Polymorphism; SNP; miR146a; miRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Australia
Breast Neoplasms / genetics*
Case-Control Studies
Female
Genetic Predisposition to Disease
Humans
MicroRNAs / genetics*
Middle Aged
Polymorphism, Single Nucleotide*

Substances

MIRN146 microRNA, human
MicroRNAs

Supplementary concepts

Breast Cancer, Familial