Neuroglobin and Nogo-a as biomarkers for the severity and prognosis of traumatic brain injury

Biomarkers. 2015;20(6-7):495-501. doi: 10.3109/1354750X.2015.1094138. Epub 2015 Oct 15.

Abstract

Objective: To identify the early changes of serum neuroglobin and Nogo-A concentrations and the relations to traumatic brain injury (TBI) severity and prognosis.

Methods: Serum samples were obtained and analyzed from 34 patients with TBI within the first 96 h after injury. Comparative analysis combined with Glasgow Coma Scale (GCS) scores and the 6-month prognosis of these patients was performed.

Results: Significant correlations were found between peak serum neuroglobin and Nogo-A concentrations and a patient's GCS score on admission (p < 0.001). The mean peak serum neuroglobin and Nogo-A concentrations were both significantly higher in patients with an unfavorable outcome at 6 months after injury (p < 0.05).

Conclusions: Serum neuroglobin and Nogo-A levels could be suggested as biomarkers for predicting TBI severity and prognosis.

Keywords: Biomarker; Nogo-A; neuroglobin; prognosis; traumatic brain injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood*
  • Brain Injuries / blood*
  • Brain Injuries / diagnosis
  • Female
  • Glasgow Coma Scale
  • Globins
  • Humans
  • Male
  • Middle Aged
  • Myelin Proteins / blood*
  • Nerve Tissue Proteins / blood*
  • Neuroglobin
  • Nogo Proteins
  • Prognosis
  • Prospective Studies
  • ROC Curve
  • Time Factors
  • Young Adult

Substances

  • Biomarkers
  • Myelin Proteins
  • Nerve Tissue Proteins
  • Neuroglobin
  • Nogo Proteins
  • RTN4 protein, human
  • Globins