DyNAvectors: dynamic constitutional vectors for adaptive DNA transfection

Lilia Clima; Dragos Peptanariu; Mariana Pinteala; Adrian Salic; Mihail Barboiu

doi:10.1039/c5cc06715d

DyNAvectors: dynamic constitutional vectors for adaptive DNA transfection

Chem Commun (Camb). 2015 Dec 25;51(99):17529-31. doi: 10.1039/c5cc06715d.

Authors

Lilia Clima¹, Dragos Peptanariu¹, Mariana Pinteala¹, Adrian Salic², Mihail Barboiu³

Affiliations

¹ Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy - 41A, Aleea Gr. Ghica Voda, Iasi, Romania.
² Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
³ Adaptative Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM/UMII/UMR-CNRS 5635, Pl. Eugène Bataillon, CC 047, 34095 Montpellier, Cedex 5, France. mihail-dumitru.barboiu@univ-montp2.fr.

PMID: 26469153
DOI: 10.1039/c5cc06715d

Abstract

Dynamic constitutional frameworks, based on squalene, PEG and PEI components, reversibly connected to core centers, allow the efficient identification of adaptive vectors for good DNA transfection efficiency and are well tolerated by mammalian cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry*
DNA / genetics
Genetic Vectors*
HeLa Cells
Humans
Microscopy, Electron, Transmission
Transfection*

Substances

DNA