Successful Extracorporeal Life Support in a Case of Severe Glyphosate-Surfactant Intoxication

Crit Care Med. 2016 Jan;44(1):e45-7. doi: 10.1097/CCM.0000000000001352.

Abstract

Objective: To describe the experience of emergency extracorporeal membrane oxygenation in treating life-threatening glyphosate-surfactant intoxication.

Design: Case report.

Setting: Emergency department and ICU.

Patient: A patient with cardiopulmonary failure after glyphosate-surfactant intoxication.

Intervention: Extracorporeal membrane oxygenation.

Case report: A 47-year-old man presented with mildly decreased consciousness in our emergency department after ingesting approximately 100 mL of glyphosate-surfactant 1.5 hours previously. Respiratory failure, persistent ventricular tachycardia, profound shock refractory to inotropic agents, and metabolic acidosis developed in the patient within 2 hours. Extracorporeal membrane oxygenation was applied within 4 hours of cardiopulmonary failure. The patient's condition improved considerably. He was transferred to the general ward on the eighth day with stable hemodynamic status and complete neurological recovery.

Conclusions: On the basis of our research, this was the first case in which extracorporeal membrane oxygenation was used to treat severe glyphosate-surfactant intoxication. We recommend early initiation of extracorporeal membrane oxygenation therapy to mitigate cardiopulmonary compromise in patients with glyphosate-surfactant intoxication.

Publication types

  • Case Reports

MeSH terms

  • Emergency Treatment
  • Extracorporeal Membrane Oxygenation*
  • Glycine / analogs & derivatives*
  • Glycine / poisoning
  • Glyphosate
  • Herbicides / poisoning*
  • Humans
  • Male
  • Middle Aged
  • Poisoning / therapy
  • Remission Induction
  • Severity of Illness Index

Substances

  • Herbicides
  • Glycine