Histological Changes in Pancreatic Islets of Animals with Experimental Diabetes Caused by Xanthurenic Acid under Condition of Suppression of Its Endogenous Synthesis

Bull Exp Biol Med. 2015 Sep;159(5):680-4. doi: 10.1007/s10517-015-3046-y. Epub 2015 Oct 14.

Abstract

Long-term administration of pyridoxine to rats kept on a diabetogenic diet stimulating endogenous synthesis of xanthurenic acid resulted in minimal glycemia, less pronounced decrease in insulin content in β-cells, and more intensive excretion of xanthurenic acid with urine. Histological changes were observed in 23% pancreatic islets, whereas in rats not treated with pyridoxine, destruction and necrosis of 40-45% β-cells were found in 38% of studied islets.

Keywords: Zn 2+ ions; pyridoxine; xanthurenic diabetes; β-cells.

MeSH terms

  • Animals
  • Animals, Newborn
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Experimental / drug therapy
  • Diabetes Mellitus, Experimental / etiology
  • Diabetes Mellitus, Experimental / metabolism
  • Diabetes Mellitus, Experimental / pathology*
  • Food, Formulated / adverse effects
  • Hypoglycemic Agents / pharmacology*
  • Immunohistochemistry
  • Insulin / blood
  • Islets of Langerhans / drug effects
  • Islets of Langerhans / metabolism
  • Islets of Langerhans / pathology
  • Islets of Langerhans / ultrastructure*
  • Pyridoxine / pharmacology*
  • Rats
  • Rats, Inbred Lew
  • Rats, Wistar
  • Xanthurenates / antagonists & inhibitors*
  • Xanthurenates / metabolism

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Xanthurenates
  • xanthurenic acid
  • Pyridoxine