Abstract
Long-term administration of pyridoxine to rats kept on a diabetogenic diet stimulating endogenous synthesis of xanthurenic acid resulted in minimal glycemia, less pronounced decrease in insulin content in β-cells, and more intensive excretion of xanthurenic acid with urine. Histological changes were observed in 23% pancreatic islets, whereas in rats not treated with pyridoxine, destruction and necrosis of 40-45% β-cells were found in 38% of studied islets.
Keywords:
Zn 2+ ions; pyridoxine; xanthurenic diabetes; β-cells.
MeSH terms
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Animals
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Animals, Newborn
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Blood Glucose / metabolism
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Diabetes Mellitus, Experimental / drug therapy
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Diabetes Mellitus, Experimental / etiology
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Diabetes Mellitus, Experimental / metabolism
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Diabetes Mellitus, Experimental / pathology*
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Food, Formulated / adverse effects
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Hypoglycemic Agents / pharmacology*
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Immunohistochemistry
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Insulin / blood
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Islets of Langerhans / drug effects
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Islets of Langerhans / metabolism
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Islets of Langerhans / pathology
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Islets of Langerhans / ultrastructure*
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Pyridoxine / pharmacology*
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Rats
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Rats, Inbred Lew
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Rats, Wistar
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Xanthurenates / antagonists & inhibitors*
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Xanthurenates / metabolism
Substances
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Blood Glucose
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Hypoglycemic Agents
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Insulin
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Xanthurenates
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xanthurenic acid
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Pyridoxine