Ketoacidosis in diabetic pregnancy

J Matern Fetal Neonatal Med. 2016 Sep;29(17):2889-95. doi: 10.3109/14767058.2015.1107903. Epub 2015 Nov 23.

Abstract

Diabetic ketoacidosis (DKA) is a serious medical and obstetrical emergency previously considered typical of type 1 diabetes but now reported also in type 2 and GDM patients. Although it is a fairly rare condition, DKA in pregnancy can compromise both fetus and mother. Metabolic changes occurring during pregnancy predispose to DKA in fact it can develop even in setting of normoglycemia. This article will provide the reader with information regarding the pathophysiology underlying DKA, in particular euglycemic DKA, and will provide information regarding all possible effects of ketones on the fetus.

Keywords: Diabetes; ketoacidosis; pregnancy.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes, Gestational*
  • Diabetic Ketoacidosis*
  • Female
  • Fetus / metabolism
  • Humans
  • Ketones / metabolism
  • Pregnancy
  • Pregnancy in Diabetics*
  • Risk Factors

Substances

  • Ketones