A Polyamine Twist on Hedgehog Signaling

Xuesong Zhao; Rosalind A Segal

doi:10.1016/j.devcel.2015.09.024

A Polyamine Twist on Hedgehog Signaling

Dev Cell. 2015 Oct 12;35(1):1-2. doi: 10.1016/j.devcel.2015.09.024.

Authors

Xuesong Zhao¹, Rosalind A Segal²

Affiliations

¹ Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
² Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: rosalind_segal@dfci.harvard.edu.

PMID: 26460938
DOI: 10.1016/j.devcel.2015.09.024

Abstract

The Hedgehog pathway plays important roles in embryonic development and oncogenesis, but how it affects metabolism is less clear. D'Amico et al. (2015) now demonstrate that the Hedgehog pathway regulates translation of ornithine decarboxylase, thereby enhancing polyamine biosynthesis and cell proliferation in neural precursor cells and in brain tumors.

Publication types

Comment

MeSH terms

AMP-Activated Protein Kinases / metabolism*
Animals
Cell Proliferation*
Female
Hedgehog Proteins / metabolism*
Humans
Medulloblastoma / pathology*
Neurons / cytology*
Ornithine Decarboxylase / metabolism*
Polyamines / metabolism*

Substances

Hedgehog Proteins
Polyamines
AMP-Activated Protein Kinases
Ornithine Decarboxylase