Hematopoietic Stem Cell Transplant for Immune Deficiency and Immune Dysregulation Disorders

David Hagin; Lauri Burroughs; Troy R Torgerson

doi:10.1016/j.iac.2015.07.010

Hematopoietic Stem Cell Transplant for Immune Deficiency and Immune Dysregulation Disorders

Immunol Allergy Clin North Am. 2015 Nov;35(4):695-711. doi: 10.1016/j.iac.2015.07.010. Epub 2015 Sep 4.

Authors

David Hagin¹, Lauri Burroughs², Troy R Torgerson³

Affiliations

¹ Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USA; University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA; Seattle Children's Research Institute, 1900 9th Avenue, JMB-7, Seattle, WA 98101-1304, USA.
² Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USA; University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA; Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Suite D3-100, Seattle, WA 98109, USA.
³ Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USA; University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA; Seattle Children's Research Institute, 1900 9th Avenue, JMB-7, Seattle, WA 98101-1304, USA. Electronic address: troy.torgerson@seattlechildrens.org.

PMID: 26454314
DOI: 10.1016/j.iac.2015.07.010

Abstract

Primary immunodeficiency disorders were among the first diseases in which hematopoietic stem cell transplant (HSCT) was attempted. Initial attempts at HSCT were discouraging and fraught with complications, but with increased knowledge and sophistication of HLA typing and donor matching, development of improved transplant conditioning regimens, and advances in prophylaxis and treatment of graft-versus-host disease, there has been a marked improvement in outcomes. This improvement has allowed an ever-growing number of different immunodeficiency and immune dysregulation disorders to be treated by HSCT. This article provides an overview of the approach to HSCT in these disorders.

Keywords: BMT; Conditioning; GVHD; GVT; HSCT; PIDD; Rejection.

Publication types

Review

MeSH terms

Donor Selection
Graft Rejection / immunology
Graft vs Host Disease / etiology
Graft vs Host Disease / prevention & control
Hematopoietic Stem Cell Transplantation* / adverse effects
Hematopoietic Stem Cell Transplantation* / methods
Hematopoietic Stem Cells / cytology
Humans
Immunologic Deficiency Syndromes / diagnosis
Immunologic Deficiency Syndromes / etiology
Immunologic Deficiency Syndromes / therapy*
Transplantation Chimera
Transplantation Conditioning / methods
Treatment Outcome