Orbital Metastases of Neuroendocrine Tumors Treated With 177Lu-DOTATATE PRRT or 131I-MIBG Therapies

Clin Nucl Med. 2016 Feb;41(2):137-41. doi: 10.1097/RLU.0000000000001008.

Abstract

Neuroendocrine tumors have a propensity to metastasize to the orbit, although the reason is unknown. A review of 251 neuroendocrine tumors treated with Lu-DOTATATE or I-MIBG at our institution since 2003 revealed 4 patients with orbital metastases (1.6%), 2 treated with Lu-DOTATATE and 2 with I-MIBG. Of these 4 patients, 1 patient was symptomatic with diplopia and eye pain, and 2 patients had physical signs of orbital involvement. The symptomatic orbital metastasis improved with Lu-DOTATATE therapy, and proptosis improved with I-MIBG therapy in 1 of 2 patients. We present the imaging findings of these 4 patients, as well as their management.

Publication types

  • Case Reports

MeSH terms

  • 3-Iodobenzylguanidine / therapeutic use*
  • Humans
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / radiotherapy*
  • Octreotide / analogs & derivatives*
  • Octreotide / therapeutic use
  • Orbital Neoplasms / radiotherapy*
  • Orbital Neoplasms / secondary
  • Organometallic Compounds / therapeutic use*
  • Radiopharmaceuticals / therapeutic use*

Substances

  • Organometallic Compounds
  • Radiopharmaceuticals
  • 3-Iodobenzylguanidine
  • lutetium Lu 177 dotatate
  • Octreotide