Abstract
We report a new crosslinked polymersome with pH-responsive swelling properties through acidic hydrolysis of hydrophobic contents from the amphiphilic polymer chains. Its unique stability under physiological conditions and large swelling capability under low pH conditions give this polymersome promising potential for anticancer drug delivery.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacokinetics
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Cell Survival
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Doxorubicin / chemistry*
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Doxorubicin / pharmacology*
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Drug Delivery Systems
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Hydrogen-Ion Concentration
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Hydrophobic and Hydrophilic Interactions
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Particle Size
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Polymers / chemistry*
Substances
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Antineoplastic Agents
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Polymers
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Doxorubicin