Mycemycins A-E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes

Ning Liu; Fangying Song; Fei Shang; Ying Huang

doi:10.3390/md13106247

Mycemycins A-E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes

Mar Drugs. 2015 Sep 30;13(10):6247-58. doi: 10.3390/md13106247.

Authors

Ning Liu¹, Fangying Song^{2

3}, Fei Shang⁴, Ying Huang⁵

Affiliations

¹ State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. fussliu@126.com.
² State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. songfangying_@126.com.
³ University of Chinese Academy of Sciences, Beijing 100049, China. songfangying_@126.com.
⁴ Analytical and Testing Center, Beijing University of Chemical Technology, Beijing 100029, China. sjynm220@126.com.
⁵ State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. huangy@im.ac.cn.

Abstract

Five new dibenzoxazepinone derivatives, mycemycins A-E (1-5), were isolated from the ethanol extracts of mycelia of two different streptomycetes. 1 and 2 were isolated from an acidic red soil-derived strain, Streptomyces sp. FXJ1.235, and 3-5 from a gntR gene-disrupted deep-sea strain named Streptomyces olivaceus FXJ8.012Δ1741. The structures of mycemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques.

Keywords: Streptomyces; deep-sea; dibenzoxazepinone; gene disruption; mycemycin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dibenzoxazepines / chemistry
Dibenzoxazepines / isolation & purification
Magnetic Resonance Spectroscopy
Species Specificity
Spectrum Analysis / methods
Streptomyces / chemistry*
Streptomyces / classification

Substances

Dibenzoxazepines