Structural basis of template-boundary definition in Tetrahymena telomerase

Nat Struct Mol Biol. 2015 Nov;22(11):883-8. doi: 10.1038/nsmb.3101. Epub 2015 Oct 5.

Abstract

Telomerase is required to maintain repetitive G-rich telomeric DNA sequences at chromosome ends. To do so, the telomerase reverse transcriptase (TERT) subunit reiteratively uses a small region of the integral telomerase RNA (TER) as a template. An essential feature of telomerase catalysis is the strict definition of the template boundary to determine the precise TER nucleotides to be reverse transcribed by TERT. We report the 3-Å crystal structure of the Tetrahymena TERT RNA-binding domain (tTRBD) bound to the template boundary element (TBE) of TER. tTRBD is wedged into the base of the TBE RNA stem-loop, and each of the flanking RNA strands wraps around opposite sides of the protein domain. The structure illustrates how the tTRBD establishes the template boundary by positioning the TBE at the correct distance from the TERT active site to prohibit copying of nontemplate nucleotides.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Crystallography, X-Ray
  • Models, Molecular
  • Protein Conformation
  • RNA / chemistry*
  • RNA / metabolism*
  • Telomerase / chemistry*
  • Telomerase / metabolism*
  • Templates, Genetic*
  • Tetrahymena thermophila / enzymology*

Substances

  • telomerase RNA
  • RNA
  • Telomerase

Associated data

  • PDB/5C9H