Selective functionalization of mesoporous silica nanoparticles with ibuprofen and Gd(III) chelates: a new probe for potential theranostic applications

Dalton Trans. 2015 Nov 7;44(41):17927-31. doi: 10.1039/c5dt03144c. Epub 2015 Oct 5.

Abstract

Organo-modified mesoporous silica nanoparticles, loaded with ibuprofen into the pores and functionalized on the external surface with a stable Gd(iii)-DOTA-monoamide chelate, were prepared and explored as potential theranostic probes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Chelating Agents / chemistry*
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Humans
  • Ibuprofen / administration & dosage*
  • Ibuprofen / chemistry
  • Ibuprofen / therapeutic use
  • Magnetic Resonance Imaging
  • Models, Molecular
  • Nanoparticles / chemistry*
  • Porosity
  • Silicon Dioxide / chemistry*
  • Theranostic Nanomedicine*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Chelating Agents
  • Heterocyclic Compounds, 1-Ring
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • Silicon Dioxide
  • Ibuprofen