Abstract
The emergence of antimicrobial resistance has created a need for the development of novel antibacterial therapies to treat infection. Natural products that exhibit antibacterial activity offer validated starting points for library generation, and the authors report here that small molecule mimics of tetramate-containing natural products may show antibacterial activity and offer the potential for further optimization.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Biological Products / chemistry*
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Biological Products / pharmacology
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Drug Resistance, Bacterial / drug effects
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Phenotype
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Pyrrolidinones / chemistry
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Pyrrolidinones / pharmacology
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Tenuazonic Acid / analogs & derivatives
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Tenuazonic Acid / chemistry
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Tenuazonic Acid / pharmacology
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Tetrahydronaphthalenes / chemistry
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Tetrahydronaphthalenes / pharmacology
Substances
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Anti-Bacterial Agents
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Biological Products
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Pyrrolidinones
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Tetrahydronaphthalenes
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reutericyclin
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equisetin
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Tenuazonic Acid