Associations of pancreatic β-cell function and insulin resistance with microalbuminuria in type 2 diabetes

Xun Sun; Ye Xiao; Bin Wang; Wen-Shan Lv; Ying Liu; Ying Chen; Yan-Gang Wang

doi:10.1016/j.diabres.2015.09.012

Associations of pancreatic β-cell function and insulin resistance with microalbuminuria in type 2 diabetes

Diabetes Res Clin Pract. 2015 Dec;110(3):e22-6. doi: 10.1016/j.diabres.2015.09.012. Epub 2015 Sep 24.

Authors

Xun Sun¹, Ye Xiao², Bin Wang³, Wen-Shan Lv³, Ying Liu³, Ying Chen³, Yan-Gang Wang⁴

Affiliations

¹ Department of Endocrinology, Weihai Hospital Affiliated to Medical College of Qingdao University, Weihai 264200, China; Department of Endocrinology and Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.
² Department of Endocrinology, Weihai Hospital Affiliated to Medical College of Qingdao University, Weihai 264200, China.
³ Department of Endocrinology and Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.
⁴ Department of Endocrinology and Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address: xiaoying0374@163.com.

PMID: 26428073
DOI: 10.1016/j.diabres.2015.09.012

Abstract

We investigate the relationships of pancreatic β-cell function and insulin resistance with microalbuminuria in a cross-sectional study of patients with type 2 diabetes. The study suggests insulin resistance is associated with an increased prevalence of microalbuminuria, while improved pancreatic β-cell function is linked to decreased rates of microalbuminuria for those patients.

Keywords: Insulin resistance; Microalbuminuria; Pancreatic β-cell function; Type 2 diabetes.

MeSH terms

Adult
Aged
Albuminuria / complications*
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / complications*
Female
Humans
Insulin Resistance*
Insulin-Secreting Cells / cytology*
Male
Middle Aged
Prevalence