Abstract
The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C δ (PKCδ) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl3 as a catalyst.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / chemical synthesis*
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Acetophenones / chemistry
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Angiogenesis Inhibitors / chemistry*
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Angiogenesis Inhibitors / pharmacology
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Benzopyrans / chemical synthesis*
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Benzopyrans / chemistry
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Catalysis
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Chalcones / chemical synthesis
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Chalcones / chemistry*
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Humans
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Phosphorylation
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Protein Kinase C-delta / chemistry*
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Protein Kinase C-delta / metabolism
Substances
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Acetophenones
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Angiogenesis Inhibitors
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Benzopyrans
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Chalcones
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kamalachalcone A
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rottlerin
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Protein Kinase C-delta