Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

Thomas M Kohl; Christian H Hornung; John Tsanaktsidis

doi:10.3390/molecules201017860

Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

Molecules. 2015 Sep 25;20(10):17860-71. doi: 10.3390/molecules201017860.

Authors

Thomas M Kohl¹, Christian H Hornung², John Tsanaktsidis³

Affiliations

¹ CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia. Thomas.Kohl@csiro.au.
² CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia. christian.hornung@csiro.au.
³ CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia. john.tsanaktsidis@csiro.au.

Abstract

Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.

Keywords: amination; continuous flow processing; flow chemistry; process intensification.

MeSH terms

Amination
Chemistry Techniques, Synthetic*
Esters

Substances

Esters